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. 2022 Apr 22;10(5):1833–1845. doi: 10.1016/j.gendis.2022.03.018

Figure 2.

Figure 2

Tissue expression profiles of hypoxia inducible gene domain (HIGD) family genes, and sequence alignment of Higd1a proteins among species. (A) The tissue expression profiles of HIGD family genes in mammals, including Higd1a, Higd1b, Higd1c, Higd1d and Higd2a. Rcf1 and Rcf2 are the names for HIGD genes in yeast. The yeast Rcf1 is also found in mammals, but Rcf2 merely exists in yeast. Higd1a and Higd2a are the mammalian homologs of Rcf1. (B) Comparison of Higd1a protein sequences of human, rhesus macaque, mouse, rat and pig. Among the 5 sequences, 3 identical residues are represented in blue; 4 identical residues are represented in red; 5 identical residues are represented in dark blue.