Figure 3.

Applying pseudotyped LVs for cancer gene therapy. Four types of pseudotypes depicted here have been demonstrated to delivery transgenes, including suicide genes, CAR genes or other therapeutic genes into targeted cells, based on the specific interactions between pseudotyping glycoproteins and corresponding cellular receptors for vector entry. The suicide gene transduction of tumor cells leads to direct cell killing. While the transduction of immune cells, such as T cells, B cells or NK cells, can boost cancer immunotherapy, thus evoking tumoricidal activities. CAR, chimeric antigen receptor.