Table 2.

CNN performance in detecting PH in each of the test datasets

	AUC	Sensitivity	Specificity	PPV, %	NPV, %	PH+ in test set, n	Controls in test set, n	Disease prevalence in dataset
PH at a prevalence of 20%	0.89 (0.88-0.90)	0.79 (0.76-0.81)	0.84 (0.83-0.85)	0.56 (0.53-0.58)	0.94 (0.93-0.95)	982	3903	20
PH at a prevalence of 1%	0.88 (0.83-0.93)	0.79 (0.68-0.90)	0.84 (0.83-0.85)	0.05 (0.03-0.06)	1.00 (1.00-1.00)	39	3903	1
Pre-capillary PH	0.91 (0.89-0.94)	0.83 (0.78-0.88)	0.84 (0.83-0.88)	0.17 (0.14-0.19)	0.99 (0.99-0.99)	147	87	63
Group 1 PH – PAH	0.94 (0.92-0.96)	0.88 (0.83-0.93)	0.84 (0.83-0.85)	0.15 (0.12-0.17)	1.0 (0.99-1.0)	119	87	56
Group 3 PH – PH due to lung disease and/or hypoxia	0.9 (0.89-0.91)	0.81 (0.77-0.84)	0.84 (0.83-0.85)	0.31 (0.29-0.34)	0.98 (0.98-0.98)	169	80	68

AUC=area under the receiver operating characteristic curve; PPV=positive predictive value; NPV=negative predictive value; PH=pulmonary hypertension; value (95% confidence interval)