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. Author manuscript; available in PMC: 2023 Aug 5.
Published in final edited form as: Pediatr Res. 2023 Jan 24;94(2):495–502. doi: 10.1038/s41390-023-02486-5

Figure 1.

Figure 1.

CBS contributes to brain H2S production (A) and pial arteriolar dilation (B) during seizures. Seizures were induced by bicuculline (3 mg/kg, i.p.) in newborn pigs, that were untreated (aCSF) or treated with selective inhibitors of CBS (AOA, 5 mM) or CSE (PPG, 5 mM) that were topically applied to the cortical surface. A: H2S concentrations in periarachnoid cerebrospinal fluid (pCSF) collected from the closed cranial windows in 10-m intervals before (Baseline) and 10–100 m after bicuculline administration. B: Dilator responses of pial arterioles to seizures 10–100 m after bicuculline administration. N = 6 pigs per group. Values are means ± SD. *P < 0.05, compared with the corresponding baseline values. †P < 0.05, compared with the corresponding values in untreated pigs.