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. Author manuscript; available in PMC: 2023 Aug 5.
Published in final edited form as: Pediatr Res. 2023 Jan 24;94(2):495–502. doi: 10.1038/s41390-023-02486-5

Figure 2.

Figure 2.

CBS inhibition aggravates long-term impairment of postictal cerebral vasodilator functions. Seizures were induced by bicuculline (3 mg/kg, i.p.) The responses of pial arterioles to topical endothelium- and astrocyte-dependent vasodilators bradykinin (BK, 10−6 M), glutamate (Glu, 10−4 M), and ADP (10−4 M) were evaluated in intact pigs and in the 48 h postictal pigs (Seizures) that were untreated (Ctrl) or treated with either the CBS inhibitor AOA (5 mg/kg, i.p.) or the CSE inhibitor PPG (5 mg/kg, i.p.) (N = 5 per group). Values are means ± SD. *P < 0.05 compared with the baseline (Base). †P < 0.05 compared with the corresponding responses in the intact group.