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Systemic administration of NaHS increases H2S in the brain (A) and dilates pial arterioles (B). NaHS (3 mg/kg) was administered parenterally (i.p.) or enterally (orogastric tube). A: H2S levels in periarachnoid cerebrospinal fluid (pCSF) collected before (0 m) and 10–80 m after NaHS administration. B: Vasodilator responses of pial arterioles to NaHS administration. N = 6 pigs per group. Values are means ± SD. *P < 0.05, compared with the baseline values.
