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. Author manuscript; available in PMC: 2023 Aug 5.
Published in final edited form as: Pediatr Res. 2023 Jan 24;94(2):495–502. doi: 10.1038/s41390-023-02486-5

Figure 5.

Figure 5.

NaHS improves long-term cerebral vascular outcome of neonatal seizures. Seizures were induced by bicuculline (3 mg/kg, i.p.) in untreated newborn pigs (seizure control, Ctrl) and in pigs treated with NaHS. NaHS (3 mg/kg) was administered parenterally (i.p.) or enterally (orogastric tube) 20 m before (preventive protocol) or 20 m after (therapeutic protocol) bicuculline administration. The responses of pial arterioles to topical endothelium- and astrocyte-dependent vasodilators A, bradykinin (10−6 M), B, glutamate (10−4 M), or C, ADP (10−4 M), and to D, the smooth muscle-dependent vasodilator sodium nitroprusside (SNP, 10−6 M) were tested in the intact group (N = 10) and in the five 48 h postictal groups, either untreated (Seizure Control) or treated with NaHS (N = 5 per group). Values are means ± SD. *P < 0.05 compared with the corresponding responses in the intact group. †P < 0.05 compared with the corresponding responses in the seizure control group.