Table 1.

Systemic circulatory parameters during seizures in newborn pigs.

Experiment	Time after Bicuculline (min)	MAPB, mm Hg	Heart Rate beats/min	Body T° (C)
Control (aCSF)	0	63 ± 8	151 ± 37	37.5 ± 0.4
	10–20	68 ± 9	235 ± 30*	37.8 ± 0.3
	30–50	65 ±7	218 ± 51*	38.2 ± 0.9
	60–90	65 ±7	210 ± 31*	38.2 ± 0.9
	100–120	60 ±8	186 ± 45	37.9 ± 0.5
+AOA	0	58 ± 6	168 ± 45	37.8 ± 0.6
	10–20	59 ± 9	253 ± 3*	37.9 ± 0.3
	30–50	60 ±8	248 ± 13*	38.2 ± 0.9
	60–90	62 ±8	220 ± 11*	38.2 ± 0.9
	100–120	58 ±9	210 ± 18	38.1 ± 0.5
+PPG	0	63 ± 5	165 ± 29	37.1 ± 0.6
	10–20	75 ± 8	251 ± 6*	37.5 ± 0.4
	30–50	69 ±7	258 ± 9*	37.6 ± 0.4
	60–90	63 ±16	250 ± 11*	37.5 ± 0.3
	100–120	62 ±11	220 ± 18*	38.5 ± 0.1

Values are means ± SD. N = 4 pigs in each group. Seizures were induced by bicuculline (3 mg/kg ip). aCSF (Control), the CBS inhibitor AOA (5 mM), or the CSE inhibitor PPG (5 mM) were placed to the brain surface under the cranial window 20 min before bicuculline and kept constant during the experiment.

^*P< 0.05 compared to the baseline values.