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Average kinetic rate constants of TTR subunit exchange in CSF.
| Tafamidis concentration (nM) | Average rate constant of subunit exchange, kex (h−1), mean ± standard error |
|---|---|
| 0 (DMSO vehicle control) | (3.4 ± 0.3) × 10−3 |
| 50 | (2.54 ± 0.08) × 10−3 |
| 125 | (2.21 ± 0.10) × 10−3 |
| 250 | (1.41 ± 0.16) × 10−3 |
| 500 | (0.78 ± 0.13) × 10−3 |
| 750 | (0.37 ± 0.06) × 10−3 |
| 1000 | (0.22 ± 0.01) × 10−3 |
