Table 1.
The upstream regulation factors of Piezo1.
| Species | Cell types | In vivo/vitro | |
|---|---|---|---|
| Sphingomyelin38 | Mouse | ECs | In vitro |
| Acidification (pk6.9)39 | Human | HEK293T cells | In vitro |
| Phosphatidylinositol 4-phosphate40 | Mouse | DRG neurons | In vitro |
| Sphingosine-1-phosphate through Src-dependent phosphorylation41 | Mouse | ECs | In vivo |
| Fatty acid42 | Mouse | N2A cells | In vitro |
| Phosphatidylserine43 | Mouse, Human | Myoblasts N2A cells, | In vitro |
| Stomatin-like protein-344−46 | Mouse | DRG neurons | In vitro |
| β-Amyloid peptide47 | Human | HEK293T cells | In vitro |
| Polycystin-248 | Monkey | COS-7 cells | In vitro |
| Trefoil factor family-149 | Human | Gastric cancer cells | In vitro |
| CD31 and VE-cadherin50 sarcoplasmic/endoplasmic | Monkey | COS-7 cells | In vitro |
| Reticulum calcium ATPase-251 | Human | HEK293T cells | In vitro |
| Spectrin and hyaluronic acid52 | Human | ECs | In vitro |