Table 2.

The downstream pathways of Piezo1.

	Species	Cell types	In vivo/vitro
β1-integrin53,54	Hamster, Human	CHO cells, 16HBE cells	In vitro
calpain12,20,53,55,56	Mouse, Hamster, Rat	ECs, CHO cells, PC12 cells	In vitro and in vivo
phosphorylation of nitric oxide synthase12, 13, 14	Mouse, Human	ECs	In vitro and in vivo
release of ATP13,22,57	Mouse, Human	Cs, Urothelial cells, red blood cells	In vitro and in vivo
adrenomedullin and P2Y2 receptor	Mouse, Human	ECs	In vitro and in vivo
G protein (αq/11 and Gs)13,14	Mouse, Human	ECs	In vitro and in vivo
yrosine phosphorylation of CD3114	Mouse, Human	ECs	In vitro and in vivo
ADAM10 and Notch signaling pathways58	Human	ECs	In vitro
AKT phosphorylation14	Mouse, Human	ECs	In vitro and in vivo
Src phosphorylation13,55	Mouse	ECs	In vitro and in vivo
Ca2+/calmodulin-dependent protein kinase II phosphorylation59,60	Drosophila, Mouse	Sensory neurons, Osteoblasts	In vitro and in vivo
VEGFR2 tyrosine phosphorylation14	Mouse, Human	ECs	In vitro and in vivo
NF-κB phosphorylation and nuclear translocation61	Mouse, Human	ECs	In vitro and in vivo
focal adhesion kinase12,61	Mouse, Human	ECs	In vitro and in vivo
VE-cadherin internalization and degradation20,50,55,62	Mouse, Monkey	Cs, COS-7 cells	In vitro and in vivo
matrix metalloproteinase-2 and membrane type matrix metalloproteinase-141	Mouse	ECs	In vivo
p38 kinase63	Mouse, Human	Fibroblasts, ECs	In vitro and in vivo
YAP1 and KLF264	Zebrafish	ECs	In vivo
phosphorylation of ERK1/2 and cyclin B65	Dog	MDCK II cells	In vitro
Na+-Ca2+ exchanger 166	Rat	Cajal-like cells	In vivo
phosphodiesterase 1 and protein kinase A67	Hamster, Human	CHO cells, A375-SM cells	In vitro
AP-1and mediate the regulation of hypoxia-inducible factor 1α by endothelin-168	Mouse	Myeloid cells	In vivo
egulate the static correlation between CD31 and G protein (αq/11)69	Human	ECs	In vitro
F-actin62	Mouse	ECs	In vivo
nuclear contraction70	Dog	MDCK cells	In vitro