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. 2022 Aug 5;10(5):2167–2178. doi: 10.1016/j.gendis.2022.07.006

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© 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — JAG1 promoted angiogenesis in the TNBC microenvironment. (A–C) GeneMANIA database was used to analyze the relationship of JAG1, VEGFA, and DLL4. (D) Analysis of the correlation of JAG1 and VEGFA via the GEPIA database. (E) CCK-8 assay was performed to detect the effect of TNBC conditioned medium on HUVEC proliferation. (F) Matrigel plug assays to detect the effect of TNBC conditioned medium on HUVEC tubulogenesis ability. (G) qRT-PCR was conducted to detect the expression of VEGFA in HUVEC treated with TNBC conditioned medium (^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001).