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. 2022 Aug 5;10(5):2167–2178. doi: 10.1016/j.gendis.2022.07.006

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© 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — JAG1 promotes exosome biogenesis and release through RAB11A and ALIX. (A) qRT-PCR to test RAB5, RAB7, RAB11A, RAB27A, RAB27B, and RAB35 expression in 231-Blank, 231 treated with DAPT, and 231 treated with rJAG1. (B) Western blotting was used to test ALIX and RAB11A protein expression in 231 treated by DAPT and rJAG1. Quantification of ALIX (C) and RAB11A (D) protein expression in (B). qRT-PCR to test lncRNA expression of SNHG16, MALAT1, and DANCR in cell (E) and exosomes (F) of 231-Blank, 231-DAPT, 231-rJAG1. (G) The uptake of tumor exosomes (Red) by HUVEC (Green) was detected by immunofluorescence assay (^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001, ^∗∗∗∗P < 0.0001).