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. 2022 Aug 6;10(5):2125–2136. doi: 10.1016/j.gendis.2022.06.010

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© 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — CHPF knockdown inhibited cell proliferation, colony formation and migration, induced cell apoptosis. (A) MTT assay was used to detect the effects of CHPF knockdown on cell proliferation of MNNG/HOS and U-2OS cells. (B) The abilities of MNNG/HOS and U-2OS cells to form colony after infection were assessed. (C, D) The effects of CHPF knockdown on MNNG/HOS and U-2OS cell migration capacities were detected by Transwell assay (C) and wound-healing assay (D). (E, F) Flow cytometry was performed to evaluate the effects of CHPF knockdown on cell cycle (E) and apoptosis (F) of MNNG/HOS and U-2OS cells. (G, H) The changes in apoptosis-related proteins were analyzed in MNNG/HOS cells following infection by a Human Apoptosis Antibody Array. Protein level was visualized by R studio (G) and presented in gray value (H). The data were expressed as mean ± SD. ∗P < 0.05, ∗∗∗P < 0.001.