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. 2022 Sep 5;10(5):1982–1993. doi: 10.1016/j.gendis.2022.08.014

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© 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — TP53BP2 interacting proteins network diagram and C-terminal binding proteins. (A) TP53BP2 interacting proteins network diagram (Quoted from the String database). (B) DNA binding domain of p53 interact with the ANK-SH3 domain at the C-terminal of TP53BP2. Asn1072 of TP53BP2 binds to Asn247 of p53 (red), and Asp1091 and Glu1092 bind to Arg273 and Arg280(blue). (C) DNA binding domain of Bcl2 interact with the ANK-SH3 domain at the C-terminal of TP53BP2. Asp950 of TP53BP2 binds to Arg164 of p53 (red), Ser1014 binds to Arg26 (blue), Glu1069 binds to Lys17 and His94 (yellow), and Asp991 binds to Arg106 (green). (D) DNA binding domain of NF-κB p65 interact with the ANK-SH3 domain at the C-terminal of TP53BP2. Glu936 of TP53BP2 binds to Lys301, Arg302, Lys303 and Arg304 of NF-κB p65, and Glu1035 binds to Arg236.