Table 1.

Expression and biological function of TP53BP2 in different tumors.

Tumor types	TP53BP2 expression in tumor	Biological function	References
Hepatocellular carcinoma	Lower expression	Promote proliferation, autophagy and chemotherapeutic drug resistance; Associated with patient prognosis and survival	11,47,48,49,50,51,52,53,54
Breast cancer	Lower expression	Promote proliferation and migration	13,53
Gastric cancer	Lower expression	Promote proliferation, migration, cell polarity and EMT	16,38,59
Endometrial endometrioid adenocarcinoma	Lower expression	TP53BP2 might become candidate markers for the early diagnosis of EEA	60
Oral cancer	Lower expression	Associated with advanced and moderately differentiated disease	61
Spinal tumor	Lower expression	Promote proliferation	62
Endometrial cancer	Lower expression	Promote cell migration	36
Esophageal squamous cell carcinoma	Lower expression	Promote ESCC generation and migration	63
Colorectal cancer	Lower expression	Promote proliferation	64
Renal cell carcinoma	Lower expression	Promote proliferation; Associated with patient prognosis	12
Gallbladder cancer	Lower expression	Promote cell migration; Associated with patient prognosis	65
Pancreatic cancer	Lower expression	Promote proliferation and chemotherapeutic drug resistance	66