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. 2022 Sep 7;10(5):1969–1981. doi: 10.1016/j.gendis.2022.08.018

Figure 3.

Fig. 3

m6A is regulated by ncRNAs. Mature miRNA binds to the 3′ untranslated region of m6A mRNA in the cytoplasm and inhibits its expression. Specifically, miR-33a can directly target the 3′ UTR of METTL3 mRNA and inhibit its expression. The miRNA let-7g downregulates its expression by targeting the 3′ UTR of METTL3, whereas mir-145 downregulates its expression by targeting the 3′ UTR of YTHDF2. In addition, the expression of METTL14, FTO, YTHDF2 and IGF2BP is also negatively regulated by miRNAs.