Table 1.
Summary of m6A posttranslational modifications.
| Molecule | Modification | Modification site | Mechanism of modification | Functions of modification |
|---|---|---|---|---|
| METTL3 | SUMOylation | Lysine residues K177, K211, K212 and K215 | m6A methyl transferase activity is significantly inhibited | Regulation of EMT progression118,119 |
| METTLE | Phosphorylation | S43/S50/S525 | Control of m6A methyl transferase activity | Loss of METTTL3/WTAP phosphorylation leaves mouse embryonic stem cells in a pluripotent state123 |
| WTAP | Phosphorylation | S306/S341 | Maintenance of the stability of the m6A methyltransferase complex | Stabilization of the m6A mRNA level in mouse embryonic stem cells123 |
| ALKBH5 | SUMOylation | / | SUMOylated ALKBH5 cannot bind to its substrate | Rapid and efficient induction ofDNA damage repair inside genes120 |
| YTHDF2 | SUMOylation | K571 | Increase the binding affinity to m6A-modified mRNA | Promotion of gene expression disorders and cancer progression62 |