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. 2022 Oct 1;10(5):2049–2063. doi: 10.1016/j.gendis.2022.09.009

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© 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — The motility regulatory network of P. aeruginosa. P. aeruginosa motility includes swarming, swimming and twitching. Swarming motility is driven by flagella, which are controlled by FleQ, two sigma factors (FliA and RpoN), two anti-sigma factors (FleN and FlgM), PA3594, and the Gac/Rsm signaling system. Swimming and twitching motility are driven by the type VI pili, which is regulated by PilRS, AlgRZ, RpoN and the Chp system. RocA1/RocR and PprB regulate the fimbriae, which are required for adherence. The motility network is mediated by 16 direct transcription regulators (such as FleQ, RpoN and PilR) and shares three co-target genes (rsmY/Z, flhA and tar-cheZ).