Figure 4.

The biofilm formation pathway regulatory network of P. aeruginosa. The P. aeruginosa biofilm matrix mainly consists of three kinds of extracellular polysaccharides (Pel, Psl and alginate extracellular polysaccharide), which are synthesised by the pelA-G operon, pslA-O operon and algD-L operon, and is regulated by 29 direct transcription regulators. We have summarised the direct regulators involved in biofilm formation and re-mapped the regulatory network underlying these regulators. The network shows 10 co-target genes: amrZ, cupD, pelA-G, fleQ, pslA-O, algU, algR, algA, algD-L and algC.