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. 2022 Oct 1;10(5):2049–2063. doi: 10.1016/j.gendis.2022.09.009

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© 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6 — The T6SS pathway regulatory network of P. aeruginosa. The T6SS signalling system is mainly controlled by Gac/Rsm-H1-T6SS and AmrZ-FleQ-H1-T6SS, and is responsible for providing competitive advantages in environments with diverse bacteria. RpoN directly binds to the promoter of two effector genes (hcpA and hcpB). H2-T6SS is directly regulated by LasR and OxyR. Effector HcpC can be secreted in host cells to cause chronic infection. The T6SS network is mediated by 18 regulators and four co-target genes (rsmY/Z, tssA1-C1, amrZ and hisA2-F2).