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. 2022 Oct 1;10(5):2049–2063. doi: 10.1016/j.gendis.2022.09.009

Figure 7.

Fig. 7

The oxidative stress response regulatory network of P. aeruginosa. Five TFs (LasR, SoxR, MexR, OxyR and OspR) involved in the QS, antibiotic resistance and motility sense ROS and translocate the signals to the downstream virulence-related phenotypes. Three metabolic proteins (ExaC, ArcA and GapA) also sense and respond to ROS from the host immune system.