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. 2022 Oct 4;10(5):2179–2193. doi: 10.1016/j.gendis.2022.09.008

Figure S5.

Figure S5

TLR4 inhibitor could partially rescue the severe inflammation of EAU caused by decreased FTO. (A) The anterior chamber inflammation and clinical scores of EAU + Vehicle, EAU + FB23-2, and EAU + FB23-2 + TAK-242 groups. Red arrows indicate conjunctival and/or ciliary congestion. Black arrows indicate infiltration of inflammatory cells. White arrow indicates posterior synechiae. (B) The retinal histopathological staining and corresponding scores of EAU + Vehicle, EAU + FB23-2, and EAU + FB23-2 + TAK-242 groups. Red arrows indicate vasculitis. Black arrows indicate infiltration of inflammatory cells. White arrow indicates retinal folds. Scale bar, 100 μm. (C) Western blot for showing the expression of TNFα and IL6 in the abovementioned three groups. n = 3. One-way ANOVA. ∗P < 0.05; ∗∗P < 0.01.