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The main way of synthesis and metabolism of H2S. Endogenous H2S is mainly produced by three enzyme-catalyzed substrates of CBS, CSE, and 3-MST, and its path mainly includes enzymatic and non-enzymatic degradation. CAT: cysteine aminotransferase; CBS: cystathionine β-synthase; CSE: cystathionine gamma-lyase; DAO: d-amino acid oxidase; 3-MST: 3-mercaptopyruvate sulfurtransferase; PLP: pyridoxal-5-phosphate; SQR: sulfide quinone oxidoreductase system.
