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. 2022 Apr 20;10(5):1870–1882. doi: 10.1016/j.gendis.2022.03.022

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© 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

S-sulfhydration plays a role in synapses and participates in memory formation. H₂S participates in memory formation through S-sulfhydration of GAPDH, SR, PKA, PKC, and CaMKII, which may all be related to LTP. AMPAR: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; CaMKII: Ca²⁺/calmodulin-dependent protein kinase II; CBS: cystathionine β-synthase; GluR1: AMPAR subunit; LTP: long-term potentiation; NMDAR: N-methyl-d-aspartate subtype glutamate receptor; PSD95: postsynaptic density 95; Siah: E3 ubiquitin protein ligase; SR: serine racemase.