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. 2023 Jul 10;14:1213351. doi: 10.3389/fimmu.2023.1213351

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Copyright © 2023 Du, Wang, Yang, Zhang, Jiang and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Animal experiment validation and single cell analysis. (A) The expression of ADM, APLNR, C3AR1 and CX3CL1 in hippocampal tissue of aged and young rat , *P <0.05 , **P <0.01. (B) The tSNE and UMAP plots of different cell clusters in the brain. (C) The tSNE and UMAP plots of cells of different age groups in the brain. (D) CX3CL1 expression is downregulated in inhibitory neurons after brain aging. (E) CX3CL1 expression is downregulated in excitatory neurons after brain aging. (F) CX3CL1 expression is downregulated in astrocytes after brain aging. (G) Radar plot of variation coefficient of CX3CL1 in six cell type. (H) Comparison of CX3CL1 variation coefficient.