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. 2023 Jul 10;14:1213351. doi: 10.3389/fimmu.2023.1213351

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Copyright © 2023 Du, Wang, Yang, Zhang, Jiang and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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WGCNA analysis. (A) β =10 is selected as the soft threshold in the combined analysis of scale independence and average connectivity. (B) Gene co-expression modules represented by different colors under the gene tree. (C) Correlation heat map of modules. (D) Heat map of the association between modules and phenotypes. Numbers at the top and bottom brackets represent the correlation coefficient and p-value, respectively. (E) β =5 is selected as the soft threshold. (F) Gene co-expression modules represented by different colors under the gene tree. (G) Correlation heat map of modules. (H) Heat map of the association between modules and brain regions. (I) Venn plot exhibiting the seven inflammaging-related genes in different brain regions. (J) GO and KEGG pathways enriched by the inflammaging genes in different brain regions.