Table 3.
Statistical analysis of diagnostic biomarkers from lipidomics.
| ID | Name | m/z | Retention time (min) |
Trend | Fold Change | p-value | VIP |
|---|---|---|---|---|---|---|---|
| Lung Qi Deficiency vs health | |||||||
| 230 | PE-O 18:1p_22:4-2 | 778.5746 | 10.79 | ↓ | 5.40E-01 | 3.29E-03 | 2.37 |
| 194 | PC-O 16:1e_22:6 | 790.5707 | 8.86 | ↑ | 1.23E+00 | 5.03E-03 | 1.86 |
| 124 | LPC-O 18:1p-5 | 506.3608 | 2.41 | ↑ | 1.62E+00 | 3.60E-03 | 1.73 |
| 308 | TG 16:0_18:0_18:0 | 881.5204 | 5.85 | ↑ | 1.32E+00 | 3.29E-03 | 1.65 |
| 204 | PE 16:0_18:3/PE 16:1_18:2 | 714.5060 | 8.19 | ↓ | 4.76E-01 | 6.97E-03 | 1.65 |
| 200 | PC-O 18:2e_22:6/PC-O 20:3_20:5e | 816.5877 | 9.11 | ↑ | 1.57E+00 | 3.60E-03 | 1.56 |
| 365 | PG 18:0_18:2/PG 18:1_18:1-2 | 804.5898 | 10.62 | ↑ | 2.38E+00 | 3.60E-03 | 1.55 |
| 151 | PC 16:0_18:3-1/PC 16:1_18:2 | 756.5539 | 7.98 | ↓ | 6.11E-01 | 0.00E+00 | 1.47 |
| 156 | PC 16:0_22:4 | 810.6023 | 9.40 | ↑ | 5.07E+00 | 0.00E+00 | 1.46 |
| 121 | LPC-O 18:0p-2 | 508.3761 | 2.69 | ↑ | 2.27E+00 | 2.32E-03 | 1.44 |
| 250 | SM d18:1_18:2/SM d18:2_18:1 | 881.5204 | 5.85 | ↓ | 7.09E-01 | 3.29E-03 | 1.43 |
| 76 | DG 18:2_22:5-1 | 684.5556 | 9.93 | ↑ | 2.88E+00 | 4.63E-03 | 1.43 |
| 14 | Cer d16:1_20:0/Cer d17:0_19:1/Cer d18:1_18:0 | 566.5495 | 10.75 | ↑ | 1.28E+00 | 3.29E-03 | 1.42 |
| 115 | LPC 24:0-2 | 608.4653 | 5.88 | ↑ | 3.00E+00 | 2.99E-03 | 1.42 |
| 198 | PC-O 18:0p_22:6 | 818.6031 | 9.99 | ↑ | 1.36E+00 | 5.03E-03 | 1.35 |
| 179 | PC 18:2_20:4 | 806.5714 | 8.06 | ↑ | 1.78E+00 | 0.00E+00 | 1.34 |
| 110 | LPC 22:5-1 | 570.3552 | 1.55 | ↑ | 2.69E+00 | 5.03E-03 | 1.33 |
| 174 | PC 18:1_22:5/PC 20:2_20:4 | 834.5992 | 9.08 | ↑ | 3.32E+00 | 2.72E-14 | 1.33 |
| 386 | PI 18:2_20:4-1 | 804.5898 | 10.62 | ↓ | 5.14E-01 | 4.63E-03 | 1.32 |
| 181 | PC 19:0_20:4 | 824.6154 | 10.29 | ↓ | 8.30E-01 | 5.03E-03 | 1.30 |
| 66 | DG 18:1_20:5-1 | 658.5397 | 9.88 | ↑ | 1.20E+00 | 8.74E-08 | 1.30 |
| 183 | PC 20:4_22:6 | 854.5687 | 7.49 | ↓ | 6.68E-01 | 3.60E-03 | 1.29 |
| 130 | LPC-O 20:1p-2 | 534.3911 | 2.33 | ↓ | 8.13E-01 | 3.60E-03 | 1.28 |
| 63 | DG 18:1_19:0 | 654.6028 | 12.23 | ↑ | 1.42E+00 | 5.03E-03 | 1.26 |
| 51 | DG 16:0_22:5/DG 18:1_20:4 | 660.5549 | 10.65 | ↑ | 1.32E+00 | 1.18E-03 | 1.21 |
| 176 | PC 18:2_18:2 | 782.5712 | 8.16 | ↑ | 1.73E+00 | 0.00E+00 | 1.21 |
| Lung-Kidney Qi Deficiency vs health | |||||||
| 151 | PC 16:0_18:3-1/PC 16:1_18:2 | 756.5539 | 7.98 | ↓ | 7.25E-01 | 0.00E+00 | 1.92 |
| 156 | PC 16:0_22:4 | 494.3241 | 1.56 | ↑ | 5.36E+00 | 0.00E+00 | 1.69 |
| 179 | PC 18:2_20:4 | 494.3241 | 1.56 | ↑ | 2.02E+00 | 0.00E+00 | 1.34 |
| Lung-Spleen Qi Deficiency vs health | |||||||
| 252 | SM d18:1_24:1 | 881.5204 | 5.85 | ↑ | 1.39E+00 | 0.00E+00 | 1.92 |
| 151 | PC 16:0_18:3-1/PC 16:1_18:2 | 756.5539 | 7.98 | ↓ | 8.20E-01 | 0.00E+00 | 1.59 |
| 247 | SM d17:1_24:1/SM d18:1_23:1/SM d18:2_23:0 | 881.5204 | 5.85 | ↓ | 8.32E-01 | 0.00E+00 | 1.47 |
| 89 | LPC 16:1 | 494.3241 | 1.56 | ↑ | 1.38E+00 | 4.43E-03 | 1.31 |
| 277 | TG 14:0_16:0_20:5/TG 14:0_18:1_18:4/TG 14:0_18:2_18:3/TG 14:1_16:0_20:4/TG 14:1_18:1_18:3/TG 14:1_18:2_18:2/TG 16:0_16:1_18:4 | 881.5204 | 5.85 | ↑ | 1.21E+00 | 0.00E+00 | 1.28 |
| 51 | DG 16:0_22:5/DG 18:1_20:4 | 660.5549 | 10.65 | ↑ | 1.22E+00 | 4.20E-04 | 1.25 |
| 229 | PE-O 18:1p_18:2 | 726.5427 | 9.73 | ↓ | 7.99E-01 | 2.90E-02 | 1.24 |
| 156 | PC 16:0_22:4 | 810.6023 | 9.40 | ↑ | 2.87E+00 | 0.00E+00 | 1.24 |
| 327 | TG 16:1_16:1_20:4 | 881.5204 | 5.85 | ↑ | 1.23E+00 | 0.00E+00 | 1.23 |
| 242 | SM d16:1_24:2/SM d18:1_22:2/SM d18:2_22:1 | 881.5204 | 5.85 | ↑ | 1.25E+00 | 3.12E-04 | 1.23 |
Details of the lipid identification and this lipid library seeing previous work (9).