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Alternative splicing of PTCH1 in MB. (A) All 18 coding exons of the PTCH1 gene are indicated by numbered boxes. (B) Alternative first exons of PTCH1 form different transcripts. (C) U1-snRNA mutations drive cryptic splicing in adults and adolescents with SHH-MB. (D) Alternative splicing of PTCH1 Exon 12b in normal brain tissues and numerous MB cell lines.
