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. 2022 Nov 9;10(5):2013–2028. doi: 10.1016/j.gendis.2022.10.014

Figure 3.

Fig. 3

Alternative splicing of GLI transcription factors in MB. (A) Alternative splicing of GLI1 in MA. (B) All coding exons of the GLI2 gene are indicated by numbered boxes, and the different color represents protein domains. (C) Four mutually exclusive 5′ non-coding exons of GLI2 with different patterns of inclusion in alternatively spliced transcripts. (D) Alternative splicing generates four GLI2 isoforms. (E) U1-snRNA mutations drive the splicing of PTCH1 and GLI2 in adults and adolescents with SHH-MB.