Figure 7.
Subgroups of MB and molecular features. (A) Clinical features, genetic alterations, and gene expression in different subgroups of SHH-MB. (B, C) Subgroups and clinical subgroups of SHH-MB and molecular features. MBSHH-infant is rich in SUFU mutations and has a good prognosis. These mutations of SUFU in MBSHH-infant all bring about aberrant splicing (Fig. 4D, E) and loss of its suppressor role. All the transcripts produced by alternative splicing have separate roles in GLI transcription factors and take parts in MB.