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. 2022 Nov 23;10(5):2082–2096. doi: 10.1016/j.gendis.2022.10.021

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© 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Effects of LRP1B on tumor progression and doxorubicin resistance. (A) Plate clone formation assay. (B) Scratch assay of HCCLM3 cells. (C) Lung metastatic foci in the lung metastasis model. (D) Photographs and growth curves of subcutaneous xenografts. (E) Immunohistochemical staining for the expression of LRP1B and Ki67 in subcutaneous xenograft tissues. (F) IC₅₀ values in different cell lines were determined based on 50% growth inhibition using a CCK-8 assay. (G) IC₅₀ values were determined in LRP1B knockdown Huh7 cells and control cells. (H) Growth curves of subcutaneous xenografts treated with doxorubicin. (I) Detection of apoptotic Huh7 cells after doxorubicin and shLRP1B treatment.