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. 2022 Nov 23;10(5):2082–2096. doi: 10.1016/j.gendis.2022.10.021

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© 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 8 — LRP1B regulates the malignant behavior of tumor cells through the PI3K/AKT/mTOR pathway. (A) Proliferation was evaluated by a CCK-8 assay. (B) Plate colony formation assays were used to detect cell proliferation. (C) Scratch assay. (D) Flow cytometry was used to detect apoptosis in transfected cells. (E) Subcutaneous xenografts in mice from the indicated groups. (F, G) Immunohistochemical staining for LRP1B (F) and NCSTN (G) in subcutaneous xenograft tissues. (H) Immunohistochemical staining for Ki-67. (I) Oil Red O staining of subcutaneous xenograft tissues.