Table 2.
Metabolomics of target tissues in mice as a result of treatment with HGD and HFD.
| HGD | HFD | |||||||
|---|---|---|---|---|---|---|---|---|
| Tissue | Metabolites | HMDB | VIP | Trend | Metabolites | HMDB | VIP | Trend |
| Serum | L-Alanine | HMDB0000161 | 2.23 | ↑ | Lysine | HMDB0000182 | 2.52 | ↑ |
| Glutamate | HMDB0000148 | 3.04 | ↑ | Glycine | HMDB0000123 | 1.59 | ↑ | |
| Glycine | HMDB0000123 | 1.20 | ↑ | Proline | HMDB0000162 | 1.58 | ↑ | |
| L-Leucine | HMDB0000687 | 1.88 | ↑ | L-Alanine | HMDB0000161 | 2.05 | ↑ | |
| Tyrosine | HMDB0000158 | 2.08 | ↑ | Tyrosine | HMDB0000158 | 1.81 | ↑ | |
| L-Aspartic acid | HMDB0000191 | 1.45 | ↑ | Glycerol | HMDB0000131 | 1.40 | ↑ | |
| Propanoic acid | HMDB0000237 | 1.83 | ↓ | Aminomalonic acid | HMDB0001147 | 1.12 | ↓ | |
| Succinic acid | HMDB0000254 | 1.66 | ↑ | Cholesterol | HMDB0000067 | 1.44 | ↑ | |
| Myo-inositol | HMDB0000211 | 1.89 | ↑ | Palmitate | HMDB0000220 | 1.48 | ↑ | |
| d-Glucose | HMDB0000122 | 1.89 | ↑ | Myo-inositol | HMDB0000211 | 1.59 | ↑ | |
| Uric acid | HMDB0000289 | 1.36 | ↓ | |||||
| Heart | L-Alanine | HMDB0000161 | 1.64 | ↑ | d-Glucose | HMDB0000122 | 1.98 | ↑ |
| Hexanoic acid | HMDB0000535 | 1.48 | ↑ | Inositol | HMDB0000211 | 2.12 | ↑ | |
| L-Valine | HMDB0000883 | 1.65 | ↑ | Adenosine | HMDB0000050 | 2.60 | ↑ | |
| L-Isoleucine | HMDB0000172 | 1.55 | ↑ | L-Alanine | HMDB0000161 | 1.46 | ↑ | |
| Uracil | HMDB0000300 | 1.62 | ↑ | Aspartic acid | HMDB0000191 | 1.10 | ↑ | |
| Serine | HMDB0062263 | 1.48 | ↑ | L-Threonine | HMDB0000167 | 1.78 | ↑ | |
| Aspartic acid | HMDB0000191 | 1.52 | ↑ | Hexane | HMDB0029600 | 1.06 | ↑ | |
| L-Glutamic acid | HMDB0000148 | 1.62 | ↑ | propanoic acid | HMDB0000237 | 1.21 | ↑ | |
| Phenylalanine | HMDB0000159 | 1.42 | ↑ | L-Glutamic acid | HMDB0000148 | 1.54 | ↑ | |
| Tyrosine | HMDB0000158 | 1.08 | ↑ | |||||
| Myo-Inositol | HMDB0000211 | 1.37 | ↑ | |||||
| Adenosine | HMDB0000050 | 1.45 | ↑ | |||||
| Liver | Alanine | HMDB0000161 | 1.13 | ↑ | Valine | HMDB0000883 | 2.21 | ↑ |
| Acetamide | HMDB0031645 | 1.80 | ↓ | 4-Aminobutanoic acid | HMDB0000112 | 2.09 | ↑ | |
| Succinic acid | HMDB0000254 | 1.55 | ↑ | Myristic acid | HMDB0000806 | 2.32 | ↑ | |
| L-Valine | HMDB0000883 | 1.33 | ↑ | d-Proline | HMDB0003411 | 1.66 | ↑ | |
| Urea | HMDB0000294 | 1.37 | ↑ | Glycine | HMDB0000123 | 2.95 | ↑ | |
| Glycine | HMDB0000123 | 1.37 | ↑ | 9,12-Octadecadienoic acid | HMDB0000673 | 2.87 | ↑ | |
| Aspartic acid | HMDB0000191 | 1.21 | ↑ | 9-Octadecenamide | HMDB0002117 | 1.94 | ↑ | |
| Pentadecanoic acid | HMDB0000826 | 1.15 | ↑ | |||||
| Galactinol | HMDB0005826 | 1.31 | ↑ | |||||
| D-Mannose | HMDB0000169 | 1.38 | ↑ | |||||
| D-Myo-Inositol | HMDB0000211 | 1.25 | ↑ | |||||
| Adenosine | HMDB0000050 | 1.16 | ↑ | |||||
| Brain | Phosphoric acid | HMDB0002142 | 1.01 | ↑ | L-Aspartic acid | HMDB0000191 | 2.44 | ↑ |
| Norleucine | HMDB0001645 | 1.83 | ↑ | Uridine | HMDB0000296 | 1.45 | ↑ | |
| L-Aspartic acid | HMDB0000191 | 1.57 | ↑ | L-(+)-Lactic acid | HMDB0000190 | 1.37 | ↑ | |
| Aminomalonic acid | HMDB0001147 | 1.55 | ↑ | L-Alanine | HMDB0000161 | 1.39 | ↑ | |
| Malic acid | HMDB0000744 | 1.21 | ↑ | |||||
| L-5-Oxoproline | HMDB0000267 | 1.09 | ↑ | |||||
| L-Phenylalanine | HMDB0000159 | 1.39 | ↑ | |||||
| Citric acid | HMDB0000094 | 1.12 | ↑ | |||||
| L-[+]-Lactic acid | HMDB0000190 | 1.21 | ↑ | |||||
| Phosphorylethanolamine | HMDB0000224 | 1.59 | ↑ | |||||
| Kidney | Glycine | HMDB0000123 | 1.92 | ↑ | L-Alanine | HMDB0000161 | 1.24 | ↑ |
| L-Leucine | HMDB0000687 | 1.13 | ↑ | L-Leucine | HMDB0000687 | 1.53 | ↑ | |
| L-Aspartic acid | HMDB0000191 | 1.40 | ↑ | L-Valine | HMDB0000883 | 1.28 | ↑ | |
| Tyrosine | HMDB0000158 | 1.56 | ↑ | Pentanedioic acid | HMDB0000661 | 1.39 | ↑ | |
| Glycerol | HMDB0000131 | 1.71 | ↑ | Phosphoric acid | HMDB0002142 | 2.00 | ↑ | |
| Xylitol | HMDB0002917 | 2.03 | ↑ | Myo-Inositol | HMDB0000211 | 1.24 | ↑ | |
| Phosphoric acid | HMDB0002142 | 1.26 | ↑ |