Table 3.
Pathway analysis by MetaboAnalyst 5.0.
| HGD | HFD | |||||
|---|---|---|---|---|---|---|
| Tissue | Pathway | Raw p | Impact | Pathway | Raw p | Impact |
| Serum | Alanine, aspartate and glutamate metabolism | 2.89E-05 | 0.42 | Phenylalanine, tyrosine and tryptophan biosynthesis | 2.63E-02 | 0.50 |
| Arginine biosynthesis | 4.21E-03 | 0.12 | Primary bile acid biosynthesis | 3.51E-02 | 0.06 | |
| Glutathione metabolism | 1.65E-02 | 0.11 | ||||
| Glyoxylate and dicarboxylate metabolism | 2.14E-02 | 0.11 | ||||
| Phenylalanine, tyrosine and tryptophan biosynthesis | 2.89E-02 | 0.50 | ||||
| D-Glutamine and D-glutamate metabolism | 4.31E-02 | 0.50 | ||||
| Heart | Phenylalanine, tyrosine and tryptophan biosynthesis | 3.46E-04 | 1.00 | Alanine, aspartate and glutamate metabolism | 4.49E-04 | 0.42 |
| Alanine, aspartate and glutamate metabolism | 1.13E-03 | 0.42 | Arginine biosynthesis | 2.78E-03 | 0.12 | |
| Phenylalanine metabolism | 3.68E-03 | 0.36 | D-Glutamine and D-glutamate metabolism | 3.54E-02 | 0.50 | |
| Arginine biosynthesis | 5.02E-03 | 0.12 | ||||
| Liver | Alanine, aspartate and glutamate metabolism | 1.13E-03 | 0.22 | Arginine and proline metabolism | 1.20E-02 | 0.02 |
| Galactose metabolism | 1.83E-02 | 0.04 | Linoleic acid metabolism | 2.31E-02 | 1.00 | |
| Brain | Alanine, aspartate and glutamate metabolism | 1.37E-02 | 0.22 | Alanine, aspartate and glutamate metabolism | 1.96E-03 | 0.22 |
| Phenylalanine, tyrosine and tryptophan biosynthesis | 2.63E-02 | 0.50 | ||||
| Kidney | Phenylalanine, tyrosine and tryptophan biosynthesis | 1.85E-02 | 0.50 | |||