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. 2023 Jul 10;11:1220405. doi: 10.3389/fcell.2023.1220405

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Copyright © 2023 Van Campenhout, Caufriez, Tabernilla, Maerten, De Boever, Sanz-Serrano, Kadam and Vinken.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structure of pannexin1 (Panx1) proteins and Panx1 channels. Panx1 proteins consist of 4 transmembrane domains (TM1-4), 2 extracellular loops (ECL1-2), 1 cytoplasmic loop (CLP), 1 cytoplasmic N-terminal (NT) and 1 cytoplasmic C-terminal tail (CT). Panx1 proteins form heptameric channels at the cell plasma membrane surface to mediate the transfer of small molecules and ions between the intracellular and extracellular space.