Effect of compounds a(1–12) and (b1–7) on plasma lipid profile in Triton WR-1339-induced hyperlipidemic rats^a.

Lipid profile	TG mg dl−1	TC mg dl−1	HDL-C mg dl−1	LDL-C mg dl−1
NG	55.2 ± 0.4	64.2 ± 0.8	41.2 ± 0.5	30 ± 0.35
HG	370 ± 3.2d	94 ± 0.71d	31.5 ± 0.36d	62.2 ± 0.91d
BZF	95.6 ± 1.8d	125.3 ± 1.5	40.2 ± 1.3b	56.0 ± 1.1
a1	75.6 ± 1.2b	89 ± 1.2b	37.6 ± 0.41b	31 ± 0.32b
a2	58.3 ± 0.9c	85 ± 0.95c	44 ± 0.65c	27 ± 0.21c
a3	340 ± 2.8	96 ± 1.6	27 ± 0.21	61 ± 0.84
a4	65 ± 0.78b	83 ± 0.75b	39 ± 0.12b	33 ± 0.12b
a5	50.2 ± 1.3d	74.5 ± 0.91d	52 ± 0.47d	25 ± 0.45d
a6	352 ± 4.6	110 ± 2.2	33 ± 0.66	67.4 ± 0.47
a7	60.4 ± 0.85c	81 ± 1.4c	41 ± 0.28c	29 ± 0.32c
a8	352.9 ± 9.5	92.7 ± 8.2	31.7 ± 3	63.4 ± 5
a9	361.3 ± 7.3	91.6 ± 5.5	29.4 ± 8	59.1 ± 7.4
a10	109.2 ± 4.7b	88.7 ± 9.5b	34.5 ± 10b	38.6 ± 4.9b
a11	20.0 ± 2.2c	62.2 ± 2.9c	49.8 ± 6c	21.2 ± 3.7c
a12	29.9 ± 4.7c	68.8 ± 4.5c	39.6 ± 6c	26.12 ± 1.2c
b1	361 ± 4.1	93 ± 2.1	30 ± 0.31	59 ± 0.42
b2	368 ± 4.3	97.3 ± 1.1	29 ± 0.45	64 ± 0.95
b3	443 ± 2.1d	96.2 ± 0.5d	30.2 ± 0.22d	71 ± 1.1d
b4	302 ± 1.1c	81.6 ± 1.9c	38 ± 0.51c	56 ± 0.4c
b5	NA	NA	NA	NA
b6	421 ± 1.9b	88.4 ± 1.2b	32 ± 0.43b	62.2 ± 0.8b
b7	390 ± 2.2c	91.2 ± 1.5c	33.2 ± 0.42c	60.1 ± 1.1c

^aValues are expressed as mean ± SEM from five rats in each group. NG, normal control group; HG, hyperlipidemic control group; BZF; bezafibrate control group, a1–a12, b1–b4, and b6–b7 + 4% DMSO for each compound, TC; total cholesterol, TG; triglyceride, HDL-C; high-density lipoprotein-cholesterol, LDL-C; low-density lipoprotein-cholesterol. All compounds are compared with HG. HG is compared with NG.

^b p < 0.05.

^c p < 0.001.

^d p < 0.0001.