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Arecoline regulates serum metabolism in positive-ion mode. (A–C) OPLS-DA based analysis showing differences among the Arec, DSS, and control groups; differences between the DSS and control groups, and differences between the Arec and DSS groups. (D) Heat map reflects the differential metabolites between the Arec and DSS groups (high levels in red, low levels in green). (E) KEGG enrichment maps of differential metabolites in the Arec and DSS groups.
