Table 1.

Summary of the cytokines associated with different JAK proteins.

JAKs	Cytokines/hormones
JAK1	IL-2, IL-4, IL-6 IL-7, IL-9, IL-10, IL-11, IL-13, IL-15, IL-19, IL-20, IL-21, IL-22, IL-24, IL-27, IL-28, IL-29, IFN-α, IFN-β, IFN-γ
JAK2	IL-3, IL-5, IL-6, IL-10, IL-11, IL-12, IL-13, IL-19, IL-20, IL-22, IL-23, IL-27, G-CSF, GM-CSF, GH, EPO, TPO, Leptin
JAK3	IL-2, IL-4, IL-7, IL-9, IL-13, IL-15, IL-21
TYK2	IL-6, IL-10, IL-11, IL-12, IL-13, IL-19, IL-20, IL-22, IL-27, IL-28, IL-29, IFN-α, IFN-β, IFN-γ

JAK, Janus kinase; IL, interleukin; IFN, interferon; GH, growth hormone; GM-CSF, granulocyte-macrophage colony stimulating factor; G-CSF, granulocyte-colony stimulating factor; EPO, Erythropoietin; TPO, thrombopoietin; TYK, tyrosine kinase.