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Group level reward pathway modulation by opioid antagonism. The forest plots display the linear random mixed effects model-derived mean and 95% confidence interval for %BOLD signal change following naltrexone. A priori regions of interest were nucleus accumbens, NAc, ventromedial prefrontal cortex, vmPFC, anterior cingulate cortex, ACC, and dorsolateral prefrontal cortex, dlPFC. Contrasts selected demonstrated Cohen’s d ≥ 0.8. *p < 0.05.
