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. 2023 May 11;3(7):100321. doi: 10.1016/j.xgen.2023.100321

Figure 2.

Figure 2

Transcriptional programs and regulators in dedifferentiated sarcoma

(A) Heatmap depicts expression (blue heat) of differentially expressed genes (rows) across the clinical specimens and cell lines (columns). Genes are grouped into coherent programs (black outlines) ordered by their correlation or anticorrelation with maturity scores. Mitochondrial genome encoded genes are grouped below. Maturity score (gray heat) and MDM2 expression (red heat) are shown above for each sample.

(B) TF binding motifs that are over-represented in DDLPS enhancers marked by H3K27ac.

(C) Scatterplot depicts expression of TFs (points) in WDLPS (y axis) and DDLPS (x axis) tumors. Points along the diagonal represent factors shared between histologies and include multiple AP1-JUN and ETS family members.

(D) Volcano plot depicts fold change and significance (p value ≤ 0.05) of differential expression of TFs (points) between WDLPS and DDLPS. TFs referenced in the text are highlighted.