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. 2023 May 11;3(7):100321. doi: 10.1016/j.xgen.2023.100321

Figure 5.

Figure 5

Supraphysiologic MDM2 localizes to nuclear foci

(A) IF images (Airyscan confocal, 63×) for representative LPS853 cell show MDM2 (green), P53 (red), and DAPI (blue).

(B) IF images (confocal, 63×) for representative LPS853 cell show MDM2 (green), PML (red), and DAPI (blue).

(C) Quantification of MDM2 and PML intensity profiles across white dashed line in (B) shows co-localization of MDM2 and PML.

(D and F) IF images (confocal, 63×) for LPS853 cells show MDM2 (green), YY1 (red), and DAPI (blue).

(E and G) High-magnification images shown for white boxed regions in (D) and (F). Bottom plots show quantifications of MDM2 (green) and YY1 (red) intensities across white dashed lines.