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. 2023 May 11;3(7):100322. doi: 10.1016/j.xgen.2023.100322

Figure 1.

Figure 1

Heterozygosity and population structure of the East African ASD cohort

(A) Heterozygosity across the human genome calculated in the East African ASD (EA ASD) cohort and the 1000 Genomes project populations from all continents. The East African genome is enriched for heterozygous variants compared with non-African genomes. Mean ± SEM are shown in black. Population abbreviations are defined in Table S8.

(B) Global admixture analysis in the East African ASD cohort and populations from the 1000 Genomes project with K = 9 indicated two admixed populations in the ASD cohort. The most closely related groups to the ancestral groups for the ASD cohort are the Luhya in Webuye, Kenya (LWK) and the Toscani in Italy (TSI). Population abbreviations are defined in Table S8.

(C) Global admixture analysis in the ASD cohort and African populations (listed in Table S9) with K = 3. While the LWK population is the most closely available African reference population, the East African ASD cohort shows distinct ancestry that clusters away from other African populations. Population abbreviations are defined in Table S9.