TABLE 1.
Clinical data of patients in the group with CWP and with dust‐exposed workers.
| Dust‐exposed workers/control group (n = 58) | CWP Stage I (n = 52) | Statistic | p‐Value | |
|---|---|---|---|---|
| Arterial blood gas analysis | ||||
| pH, mean (SD) | 7.378 (0.021) | 7.381 (0.019) | t = 0.772 | 0.442 |
| PaCO2 (mmHg), mean (SD) | 41.2 (2.694) |
40.977 (2.918) |
t = 0.005 | 0.996 |
| PaO2 (mmHg), IQR | 89.9 (9.07) | 85.95 (7.47) | Z = 0.714 | 0.475 |
| SaO2 (%), IQR | 96.3 (1.15) | 95.85 (1.32) | Z = 3.414 | <0.05 |
| AaDO2 (mmHg), IQR | 8.9 (7.09) | 13.51 (6.43) | Z = 2.128 | <0.05 |
| Pulmonary function test | ||||
| VCmax‐value (L), IQR | 4.19 (1.02) | 3.72 (0.63) | Z = 0.383 | 0.702 |
| FVC‐value (L), IQR | 4.09 (1.06) | 3.635 (0.55) | Z = 0.344 | 0.731 |
| FEV1‐value (L), IQR | 3.14 (0.94) | 2.765 (0.53) | Z = 0.467 | 0.641 |
| FEV1/FVC (%), IQR | 79.34 (6.41) | 77.595 (8.17) | Z = 0.163 | 0.871 |
| Blood cell analysis | ||||
| WBC count (×109/L), IQR | 5.5 (2.02) | 6.05 (2.0) | Z = 0.744 | 0.457 |
| NEUT%, mean (SD) | 58.98 (7.775) | 63.431 (7.814) | t = 0.003 | 0.998 |
| Total count of blood lymphocytes (×1012/L), IQR | 1.6 (0.5) | 1.6 (0.7) | Z = 1.243 | 0.214 |
| Total count of blood monocytes (×1012/L), IQR | 0.4 (0.2) | 0.4 (0.2) | Z = 1.14 | 0.254 |
| Inflammatory markers | ||||
| ESR (mm/1st h), IQR | 4.0 (4.75) | 6.5 (4.0) | Z = 2.349 | <0.05 |
| CRP (mg/L), IQR | 2.59 (2.02) | 3.12 (1.69) | Z = 1.725 | <0.05 |
| Blood biochemical parameters | ||||
| ALT (IU/L), IQR | 29.0 (14.75) | 21 (10.25) | Z = 2.635 | <0.05 |
| AST (IU/L), IQR | 27.0 (8.5) | 22 (5.25) | Z = 3.242 | <0.05 |
| GGT (IU/L), IQR | 31 (20.25) | 38.5 (73.25) | Z = 2.951 | <0.05 |
| CK (IU/L), IQR | 110.0 (61.75) | 96.5 (30.5) | Z = 1.848 | <0.05 |
| Ca2+ (mmol/L), IQR | 1.125 (0.03) | 1.1 (0.12) | Z = 2.335 | <0.05 |
| BNP (pg/mL), IQR | 9.0 (10.5) | 12 (12.0) | Z = 1.959 | <0.05 |
| HbA1c (%), IQR | 4.63 (0.46) | 5.44 (0.7) | Z = 2.367 | <0.05 |
| Coagulation function | ||||
| PT (s), IQR | 11.6 (0.7) | 11.9 (0.5) | Z = 0.795 | 0.426 |
| PTA (%), IQR | 93.8 (13.6) | 88.5 (8.6) | Z = 0.7 | 0.484 |
| INR, IQR | 1.01 (0.07) | 1.04 (0.04) | Z = 2.777 | <0.05 |
| D‐dimer (mg/L), IQR | 0.18 (0.19) | 0.26 (0.25) | Z = 2.623 | <0.05 |
| Serum tumor markers | ||||
| CEA (ng/mL), IQR | 2.12 (2.31) | 2.125 (2.05) | Z = 1.508 | 0.132 |
| SCC (ug/L), IQR | 0.71 (0.26) | 0.73 (0.42) | Z = 1.359 | 0.174 |
| CA19‐9 (U/mL), IQR | 5.27 (3.79) | 9.195 (9.65) | Z = 3.258 | <0.05 |
| CA125 (U/mL), IQR | 11.33 (3.23) | 10.925 (3.33) | Z = 1.227 | 0.220 |
Note: Bold characters represent statistical significance. Values are given as median (lower quartile, upper quartile) or n (percent).
Abbreviations: AaDO2, alveolar‐arterial oxygen difference; ALT, alanine transaminase; AST, aspartate aminotransferase; BNP, B‐natriuretic peptide;
CA125, carbohydrate antigen 125; CA19‐9, carbohydrate antigen 19‐9; CEA, carcinoembryonic antigen; CK, creatine kinase; CRP, C‐reactive protein; CWP, coal workers' pneumoconiosis; CYFRA21‐1, cytokeratin 19 fragment antigen 21‐1; ESR, Erythrocyte sedimentation rate; FEV1‐value, value of the forced expiratory volume in the first second; FVC‐value, value of forced vital capacity; GGT, gamma glutamyl transpeptidase; HbA1c, hemoglobin A1c; INR, international normalized ratio; IQR, interquartile range; NEUT%, percentage of neutrophils; NSE, neuron‐specific enolase; PaCO2, arterial carbon dioxide tension; PaO2, arterial partial pressure of oxygen; PH, hydrogen ion concentration; PT, prothrombin time; PTA, prothrombin time activity; SaO2, arterial blood oxygen saturation; SCC, squamous cell carcinoma antigen; VCmax‐value, max value of vital capacity; WBC, white blood cell.