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. 2023 May 30;14(21):2007–2017. doi: 10.1111/1759-7714.14982

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© 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The combination of patchouli alcohol (PA) and cisplatin synergistically inhibited cell growth. A549 (a) and A549/V16 (b) cells were treated with the indicated concentrations of PA and cisplatin for 48 h, and cell viability was measured using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5 diphenyl tetrazolium bromide (MTT) assay. The combination index (CI) of the data was calculated using CompuSyn software to determine the drug–drug interactions, including synergism (CI < 1), additive effects (CI = 1), and antagonism (CI > 1). Results are expressed as the mean ± SD from three independent experiments. *p < 0.05, compared with the control.