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. 2023 Jul 22;4(4):e337. doi: 10.1002/mco2.337

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© 2023 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Ubiquitin‐specific protease 5 (USP5) promotes tumor growth dependent on stabilizing lymphoid‐specific helicase (LSH). (A–C) The cell counting kit‐8 (CCK8) assay (A), transwell assay (B), and colony formation assay (C) of LM3 cells stably overexpressing USP5. Scale bars, 100 μm. (D–F) The CCK8 assay (D), transwell assay (E), and colony formation assay (F) of HepG2 cells transfected with USP5‐C335A. Scale bars, 100 μm. (G) LM3 cells stably overexpressing USP5 were transplanted on nude miced (n = 6 mice per group). (H–J) The CCK8 assay (H), transwell assay (I), and colony formation assay (J) of Hep3B cells knockout of USP5. Scale bars, 100 μm. (K) Hep3B cells knockout of USP5 were transplanted on nude mice (n = 6 mice per group). (L and M) The colony formation assay (L) and transwell assay (M) of Hep3B cells knockout of USP5 with LSH overexpression. Scale bars, 100 μm. *p < 0.05, **p < 0.01, and ****p < 0.0001.