TABLE 1.
Demographics of the ADOPIC participants selected to build the universal mask statistically. Bold font indicates statistical significance.
| Tracer | PIB | FBP | FBB | FLT | NAV | P‐value | |
|---|---|---|---|---|---|---|---|
| N pairs | 63 | 147 | 22 | 10 | 42 | ||
| Sex (% female) | HC | 0.44 | 0.5 | 0.23 | 0.4 | 0.48 | 0.21 |
| AD | 0.44 | 0.5 | 0.23 | 0.4 | 0.48 | 0.21 | |
| P‐value | 1 | 1 | 1 | 1 | 1 | ||
| Age (years) | HC | 75.4(7.9) | 76.5(7.5) | 75.4(5.8) | 75.0(4.1) | 72.9(8.5) | 0.1 |
| AD | 75.5(8.1) | 76.5(8.0) | 75.9(6.5) | 75.1(4.3) | 72.6(8.7) | 0.11 | |
| P‐value | 0.939 | 0.945 | 0.8 | 0.987 | 0.909 | ||
| MMSE | HC | 29.3(0.8) | 29.3(0.8) | 29.0(0.8) | 28.9(0.9) | 29.3(0.8) | 0.28 |
| AD | 22.1(1.4) | 22.1(1.4) | 22.2(1.6) | 21.5(1.1) | 22.1(1.4) | 0.75 | |
| P‐value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | ||
| Effect size | 6.41 | 6.57 | 5.69 | 8.61 | 6.6 | ||
| CDR (% at 0/0.5/1/2) | HC | 100/0/0/0 | 100/0/0/0 | 100/0/0/0 | 100/0/0/0 | 100/0/0/0 | 1 |
| AD | 0/46/52/2 | 0/31/66/3 | 0/41/50/9 | 0/20/70/10 | 0/50/43/7 | 0.26 | |
| P‐value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | ||
| Effect size | 3.87 | 4.05 | 3.09 | 4.06 | 2.93 | ||
| Centiloid | HC | −1.6(5.6) | −3.6(10.6) | −3.1(11.0) | 8.3(3.9) | −0.5(4.8) | <0.001 |
| AD | 90.1(26.8) | 87.5(29.3) | 88.7(33.1) | 102.1(34.3) | 98.3(36.6) | 0.22 | |
| P‐value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | ||
| Effect size | 4.84 | 4.17 | 3.98 | 4.5 | 3.92 |
Abbreviations: AD, Alzheimer's disease; ADOPIC, Alzheimer's Dementia Onset and Progression in International Cohorts; CDR, Clinical Dementia Rating; FBB, 18F‐florbetaben; FBP, 18F‐florbetapir; FLT, 18F‐flutemetamol; HC, healthy control; MMSE, Mini‐Mental State Examination; NAV, 18F‐NAV4694; PIB, 11C Pittsburgh compound B.