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. 2023 May 31;3(7):100340. doi: 10.1016/j.xgen.2023.100340

Figure 2.

Figure 2

Mutational landscape of PBTA tumors

Frequencies of canonical somatic gene mutations, CNVs, fusions, and TMB (top bar plot) for the top mutated genes across primary tumors within the OpenPBTA dataset.

(A) LGGs (n = 226): pilocytic astrocytoma (n = 104), other LGG (n = 68), ganglioglioma (n = 35), pleomorphic xanthoastrocytoma (n = 9), and subependymal giant cell astrocytoma (n = 10).

(B) Embryonal tumors (n = 129): medulloblastoma (n = 95), atypical teratoid rhabdoid tumor (n = 24), and other embryonal tumor (n = 10).

(C) HGGs (n = 63): diffuse midline glioma (n = 36) and other HGG (n = 27).

(D) Other CNS tumors (n = 153): ependymoma (n = 60), craniopharyngioma (n = 31), meningioma (n = 17), dysembryoplastic neuroepithelial tumor (n = 19), Ewing sarcoma (n = 7), schwannoma (n = 12), and neurofibroma plexiform (n = 7). Rare CNS tumors are displayed in Figure S3B. Histology (cancer group) and sex annotations are displayed under each plot. Only tumors with mutations in the listed genes are shown. Multiple CNVs are denoted as a complex event. n denotes the number of unique tumors (one tumor per patient).