Figure 3.

Mutational co-occurrence and signatures highlight key oncogenic drivers

(A) Non-synonymous mutations for 50 most commonly mutated genes across all histologies. “Other” denotes a histology with <10 tumors.

(B) Co-occurrence and mutual exclusivity of mutated genes. The co-occurrence score is defined as $I\left(-{\log }_{10}\left(P\right)\right)$ where $P$ is Fisher’s exact test and $I$ is 1 when mutations co-occur more often than expected or −1 when exclusivity is more common.

(C) Number of SV and CNV breaks are significantly correlated (adjusted R = 0.443, p = 1.05e−38).

(D) Chromothripsis frequency across cancer groups with n ≥3 tumors.

(E) Sina plots of RefSig signature weights for signatures 1, 11, 18, 19, 3, 8, N6, MMR2, and other across cancer groups. Boxplot represents 5% (lower whisker), 25% (lower box), 50% (median), 75% (upper box), and 95% (upper whisker) quantiles.