Table 1.
Molecular subtypes generated through the OpenPBTA project
| Broad histology group | OpenPBTA molecular subtype | Patients | Tumors |
|---|---|---|---|
| Chordoma | CHDM, conventional | 2 | 2 |
| CHDM, poorly differentiated | 2 | 4 | |
| Embryonal tumor | CNS embryonal, NOS | 13 | 13 |
| CNS HGNET-MN1 | 1 | 1 | |
| CNS NB-FOXR2 | 2 | 3 | |
| ETMR, C19MC altered | 5 | 5 | |
| ETMR, NOS | 1 | 1 | |
| MB, group 3 | 14 | 14 | |
| MB, group 4 | 48 | 49 | |
| MB, SHH | 24 | 30 | |
| MB, WNT | 10 | 10 | |
| Ependymoma | EPN, H3 K28 | 1 | 1 |
| EPN, ST RELA | 25 | 28 | |
| EPN, ST YAP1 | 3 | 4 | |
| High-grade glioma |
DMG, H3 K28 | 18 | 24 |
| DMG, H3 K28, TP53 activated | 10 | 13 | |
| DMG, H3 K28, TP53 loss | 30 | 40 | |
| HGG, H3 G35 | 3 | 3 | |
| HGG, H3 G35, TP53 loss | 1 | 1 | |
| HGG, H3 wild type | 26 | 31 | |
| HGG, H3 wild type, TP53 activated | 5 | 5 | |
| HGG, H3 wild type, TP53 loss | 14 | 21 | |
| HGG, IDH, TP53 activated | 1 | 2 | |
| HGG, IDH, TP53 loss | 1 | 1 | |
| Low-grade glioma |
GNG, BRAF V600E | 13 | 13 |
| GNG, BRAF V600E, CDKN2A/B | 1 | 1 | |
| GNG, FGFR | 1 | 1 | |
| GNG, H3 | 1 | 1 | |
| GNG, IDH | 1 | 2 | |
| GNG, KIAA1549-BRAF | 5 | 5 | |
| GNG, MYB/MYBL1 | 1 | 1 | |
| GNG, NF1-germline | 1 | 1 | |
| GNG, NF1-somatic, BRAF V600E | 1 | 1 | |
| GNG, other MAPK | 4 | 4 | |
| GNG, other MAPK, IDH | 1 | 1 | |
| GNG, RTK | 2 | 3 | |
| GNG, wild type | 14 | 14 | |
| LGG, BRAF V600E | 25 | 27 | |
| LGG, BRAF V600E, CDKN2A/B | 5 | 5 | |
| LGG, FGFR | 8 | 8 | |
| LGG, IDH | 3 | 3 | |
| LGG, KIAA1549-BRAF | 106 | 113 | |
| LGG, KIAA1549-BRAF, NF1-germline | 1 | 1 | |
| LGG, KIAA1549-BRAF, other MAPK | 1 | 1 | |
| LGG, MYB/MYBL1 | 2 | 2 | |
| LGG, NF1-germline | 6 | 6 | |
| LGG, NF1-germline, CDKN2A/B | 1 | 1 | |
| LGG, NF1-germline, FGFR | 1 | 2 | |
| LGG, NF1-somatic | 2 | 2 | |
| LGG, NF1-somatic, FGFR | 1 | 1 | |
| LGG, NF1-somatic, NF1-germline, CDKN2A/B | 1 | 1 | |
| LGG, other MAPK | 11 | 12 | |
| LGG, RTK | 8 | 10 | |
| LGG, RTK, CDKN2A/B | 1 | 1 | |
| LGG, wild type | 33 | 34 | |
| SEGA, RTK | 1 | 1 | |
| SEGA, wild type | 10 | 11 | |
| Mesenchymal non-meningothelial tumor | EWS | 9 | 11 |
| Neuronal and mixed neuronal-glial tumor | CNC | 2 | 2 |
| EVN | 1 | 1 | |
| GNT, BRAF V600E | 1 | 1 | |
| GNT, KIAA1549-BRAF | 1 | 2 | |
| GNT, other MAPK | 1 | 1 | |
| GNT, other MAPK, FGFR | 1 | 1 | |
| GNT, RTK | 1 | 2 | |
| Tumor of sellar region | CRANIO, ADAM | 27 | 27 |
| Total | – | 577 | 644 |
Broad tumor histologies, molecular subtypes generated, and number of patients and tumors subtyped within the OpenPBTA.